AstraZeneca along with researchers from the Swedish Medical University Karolinska Institutet designed a series of studies of COPD in pairs of Twins to determine the contribution of environmental factors and inherited genes in the development of the disease.
Because identical twins have the same genetic makeup, and fraternal twins share ~50 per cent of their genes, twin studies provide an interesting opportunity to study the interplay of genetic and environmental causes of disease in COPD. Both chronic bronchitis and emphysema are surrogates for COPD.
for more information :
http://www.astrazeneca.com/Article/511824.aspx
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